Research and Innovation

Research and Innovation

Empowering Future Generations of Pharmacists

At Hygia Institute of Pharmacy, we are committed to advancing the field of pharmacy through innovative research and education. Our research focus areas include pharmaceutical sciences, pharmacology and toxicology, pharmaceutical analysis, and pharmacy practice.

Research Focus Areas

• Pharmaceutical Sciences: Drug discovery, development, and delivery
• Pharmacology and Toxicology: Mechanisms of action and potential toxic effects
• Pharmaceutical Analysis: Development and validation of analytical methods
• Pharmacy Practice: Medication adherence, patient safety, and outcomes

Innovation Initiatives

• Incubation Center: Supporting startup companies and entrepreneurs in the pharmaceutical sector
• Mentorship Programs: Guiding students and young entrepreneurs in developing innovative ideas
• Collaborations and Partnerships: Working with industry partners, research institutions, and government agencies to advance innovation

Research Facilities

• Pharmaceutical Research Laboratory: Modern instrumentation and equipment for pharmaceutical research
• Animal House: Well-equipped facility for conducting animal studies
• Computer-Aided Drug Design Laboratory: Software and hardware for computer-aided drug design

1.     Box–Behnken Design Based Optimized Quercetin Nano Formulation for Palliative Treatment of Atopic Dermatitis. DOI: https://doi.org/10.1016/j.jddst.2024.106228     

2.     Crisaborole Enthused Glycerosomal Gel for an Augmented Skin Permeation.DOI: 10.2174/0126673878283299240418112318.

3.     A Comprehensive Review on Polyphenols Based Nanovesicular System for Topical Delivery . doi: 10.2174/0115672018265118231213094410.

4.     Crisaborole loaded nanoemulgel for the mitigation of atopic dermatitis in mice model.doi: 10.1080/03639045.2023.2244075.

5.     Glibenclamide-malonic acid cocrystal with an enhanced solubility and bioavailability.doi: 10.1080/03639045.2022.2122987.

6.     A Discursive Review of Recent Development and Patents on Glycerosomes.. doi: 10.2174/1872210516666220328124450.

7.     Efficacy of Flavonoids in Combating Fluconazole Resistant Oral Candidiasis” Curr Pharm Des. 10.2174/1381612828666220324140257.

8.     Assessment of the Impact of Herbal Drugs Used in Neurodegenerative Disorders: A Preclinical Review.”  https://doi.org/10.2174/2215083808666220509224739.

9.     Antimicrobial and Wound Healing Potential of Dietary Flavonoid Naringenin The Natural Products .https://doi.org/10.2174/2210315508666180802104630 .

10.  Multicomponent Pharmaceutical Cocrystals: A Novel Approach for Combination 10.2174/1389557518666180305163613.

11.  Phytochemical analysis and simultaneous quantification of quercetin and gallic acid in Ipomoea carnea Jacq. through HPTLC,  DOI: 10.31838/ecb/2023.12.5.423

12.  Neuroprotective Potential of Trachyspermum Ammi Essential Oil against Monosodium Glutamate Induced Excitotoxicity by Reducing Accumulation of β-Amyloid. Journal of Biological Regulators and Homeostatic Agents. DOI: https://doi.org/10.1016/j.envpol.2022.119804

13.  Assessment of the Impact of Herbal Drugs Used in Neurodegenerative Disorders: A Preclinical Review. DOI: 10.2174/2215083808666220509224739

14.  Phytochemical: a treatment option for heavy metal induced neurotoxicity. DOI: https://doi.org/10.1515/jcim-2020-0325

15.  Pharmacological screening of ethanolic extract of Pithecellobium dulce for antiarthritic activity in Rats; DOI: 10.56042/ijnpr.v12i3.31100

16.  Exploring the effect of Naringenin against Cadmium Induced Neurotoxicity in mice model. DOI: 10.52711/0974-360X.2021.00702

17.  Fabrication, In vitro and In vivo Characterization of Solid Dispersion-Microsphere Controlled Release System for Lornoxicam. DOI: 10.2174/2210681210999200909112738

18.  Streblus asper attenuates stress-induced physical and Biochemical changes in Rat Model. DOI: 10.52711/0974-360X.2021.00337

19.  Experimental evaluation of Streblus asper hydroalcoholic extract for antistress activity. DOI: https://ijrps.com/home/article/view/1253

20.  Beneficial effects of Sambucus nigra in chronic stress-induced neurobehavioral and biochemical perturbation in rodents. DOI:10.5530/pj.2021.13.22

21.  Effect of streblus asper leaves on locomotion, anxiety and cognition in rats. DOI: https://doi.org/10.22159/ajpcr.2019.v12i2.28842

22.  Seabuckthorn (Hippophae rhamnoides and Hippophae salicifolia) seed oil in combating inflammation: A mechanistic approach. DOI: 10.4103/pr.pr_71_18

23.  Chronic Inhibition of Central Angiotensin Converting Enzyme Ameliorates Colchicine Induced Memory Impairment in Mice. doi:10.3797/scipharm.1203-06

24.  Protective effect of quercetin against intracerebral streptozotocin induced reduction in cerebral blood flow and impairment of memory in mice.  DOI: 10.1016/j.bbr.2010.01.017 19.          

25.  Protective effect of curcumin against intracerebral streptozotocin induced impairment in memory and cerebral blood flow. DOI: 10.1016/j.lfs.2009.11.007

26.  Candesartan improves memory impairment:  involvement of AT1 receptors in intracerebral Streptozotocin induced memory deficit. doi: 10.1016/j.bbr.2008.11.044.

 

27.  Quality by Design Approach for Optimization of 5-Fluorouracil Microbeads using Box–Behnken Design and Desirability Function for Colon Targeting (https://doi.org/10.1007/s12247-023-09772-z)

28.  10.Mesalamine loaded ethyl cellulose nanoparticles: optimization and in vivo evaluation of antioxidant potential in ulcerative colitis (10.1088/1748-605X/ad920e)

29.  11. A Novel Mesalamine Loaded Hybrid Nanoparticle-in-Microparticle for Colon Targeting: In-vitro and In-vivo Investigations (10.1007/s12247-024-09882-2)

30.  12. Adjuvant Novel Nanocarrier-Based Targeted Therapy for Lung Cancer (10.3390/molecules29051076) 13. Application of nanotechnology for Herbal medicine Development: A Review (10.2174/1570180820666230308105723)

31.  14.. Pathophysiology of cerebral ischemia-reperfusion injury: An overview of oxidative stress and plant-based therapeutic approaches. DOI: https://doi.org/10.1016/j.brainres.2024.149308.

32.  18.Amelioration of gastric ulcer using a hydro-alcoholic extract of Mangifera  indica in Sprague Dawley rats by prevention of muco-oxidative stress.https://doi.org/10.1016/j.prmcm.2024.100442

33.  stem cell informatics. http://dx.doi.org/10.1016/B978-0-443-13222-3.00023-X.

34.  Protein Kinases and their Inhibitors Implications in Modulating Disease Progression, http://dx.doi.org/10.1007/s10930-023-10159-9.

35.  SAXAGLIPTIN: A SYSTEMATIC REVIEW ON ITS PHARMACOLOGICAL POTENTIAL AND ANALYTICAL ASPECTS.

36.  Phytopharmaceuticals and Herbal Approaches to Target Neurodegenerative Disorders, http://dx.doi.org/10.1055/a-2076-7939. 5

37.  Therapeutic Application, Phytoactives and Pharmacology of Tinospora cordifolia: An Evocative Review, http://dx.doi.org/10.1007/s11655-023-3733-2.

38.  Hybrid Nanocarriers for Neurological Disorders: Diagnostic & Therapeutic Approach, http://dx.doi.org/10.2174/1872210516666220825170125.

39.  Current Pharmacological Trends on Myricetin, http://dx.doi.org/10.1055/a-1224-3625.

40.  A Comprehensive Review on Physiological Effects of Curcumin, http://dx.doi.org/10.1055/a-1207-9469.

41.  Curcumin nanogel preparations: a promising  alternative for psoriasis treatment.(doi- 10.2174/0113892002312605240508042634)

42.  Exploration of diacerein as neuroprotective adjuvent to Adenium obesum : An in vivo study.(DOI: 10.1016/j.jaim.2023.100761)  

43.  Microwave assisted metal-/oxidant-free cascade electrophilic sulfenylation/ 5- endo – dig cyclization of 2-alkynylanilines to generate diversified 3-sulfenylindoles.10.1016/j.tetlet.2017.08.046

a.      A comprehensive review on experimental models of Stress: Pragmatic insight into psychoneuroimmunology.10.22541/au.169735580.08163506/v1,

44.  Development and efficiency assessment of polyherbal phytosomal gel for accelerated wound healing. http://doi .org/10.1 080/0920 5063.202 4.234640 0.,

45.  Pathophysiology of cerebral ischemia reperfusion injury: An overview of oxidative stress and plant-based therapeutic approaches.https://do i.org/10.1 016/j.brai nres.202 4.149308,

46.  -Nutritional and medicinal properties of jaggery: An overview http://dx. doi.org/1 0.18535/j mscr/v12 i04.04,

47.  In silico Approachs forexploring the pharmacological activities of benzimidazole derivatives: A comprehancive review. http://dx. doi.org/1 0.2174/0 1138955 7528732 2240115 115125,

48.  Enteric coated microgranules of pantoprazole sodium in gastroesophageal reflux Diseasehttp://dx. doi.org/1 0.54085/ ap.2023. 12.1.97, ,

49.  Isolation, Characterization and evaluation of semisythetic of hesperidin derivatives from Citrus aurantium L.http://dx. doi.org/1 0.54085/ ap.2022. 11.2.0,

50.  -Alpha Amylase, Alpha Glucosidase and Glucose diffusion inhibitory activity of Vidangadi Kvatha, 09- Evaluation of the antidiabetic potential of Rumex vesicarius L. in normal and streptozotocin induced diabetic rats. DOI: 10. 5958/232 1- 5836.201 6.00023.

a.      Design, Synthesis and in-silico& in vitro enzymatic inhibition assays of pyrazole- chalcone derivatives as dual inhibitors of alpha amylase & DPP-4 enzyme. https://do i.org/10. 1016/j.bi oorg.202 1.105586, 11-

51.  Validating the properties of Nymphaea pubescens willd. by performing UV-VIS, TLC, FTIR and HPLC analyses http://dx. doi.org/1 0.13040/ IJPSR.09 75- 8232.12( 1).615- 21,

52.  Antidiabetic effect of Vidangadi Kwatha in STZ-NAD induced diabetic rats. https://dx .doi.org/ 10.18535 /jmscr/v9 i7.12,

53.  Role of Katankateryadi Kwatha in insulin secretion and restoration of biochemical changes in streptozotocin- nicotinamide induced diabetes mellitus type 2 in rats. DOI: 10.26502 /ijabpt.20 2106,

 

54.   Alpha- Amylase inhibitory activityof Katankateryadi Kwatha (K.Kwatha) in Management of Type2 Diabetes.DOI: 10. 13040/IJ PSR.097 5- 8232.12( 8).4341- 45, 15-Ethnomedical and Pharmacological properties of Phaseolus vulgaris L. An Overview.,

55.  Synergistic neuroprotective potential of combined treatment with vinpocetine and minocycline against streptozotocin and lipopolysaccharide induced memory Impaired mice. DOI: htt ps://doi.o rg/10.11 66/jpsp.2 017.1084,

56.  Encyclopedic Study of Haritaki (Terminalia Chebula Ritz.) In Reference To Prameha. JMSCR.DOI: http://dx_doi.org/10.18535/jmscr/v5i7.195,

57.  0-Adaptogenic potential of Oxitard in experimental chronic stress and chronic unpredictable stress induced dysfunctional homeostasis inrodents. https://do i.org/10. 1016/j.jai m.2017.0 1.003,

58.  Biologically Synthesized Gold Nanoparticles using Ocimum sanctum (Tulsi Leaf Extract) Induced Anti-Tumor Response in a T Cell Daltons Lymphoma. https://do i.org/10. 1016/j.jai m.2017.0 1.003,

59.  Selenium nanoparticles induce suppressed function of tumorassociated macrophages and inhibit Dalton’s lymphoma proliferation. doi: 10.1 016/j.bbr ep.2017. 09.005,

60.  Therapeutic Plants of Ayurveda: Areview on Anticancer. https://do i.org/10. 5530/pj.2011.23.1,

61.  Phytoconstituents characterization of hydroalcoholic extract of haritaki (Terminalia chebularetz.) Fruit Pericarp by uv- visspectroscopy. CorpusID:212445298.

62.  Ciprofloxacin Hydrochloride Floating In-Situ Gel for the treatment of Gastric Ulcer: Preparation and Evaluation. African Journal of Biomedical Research. .https://doi.org/10.53555/AJBR.v27i4S.4303

63.  Raft Forming Floating Tablets of Clarithromycin Using Natural Polymers for the Treatment of Peptic Ulcer: Development and Evaluation.  https://doi.org/10.53555/AJBR.v27i4S.4301 (SCOPUS)

64.  Formulation and Evaluation of Nano-Emulgel Containing Ethanolic Extract of Fruit Rinds of Garcinia indica for Wound Healing Activity.  https://doi.org/10.48047/ecb/2023.12.si7.317.

65.  Qualitative & Quantitative Estimation of Phytochemicals in Garcinia indica Fruit Rind Extract. https://doi.org/10.48047/ecb/2023.12.si7.315

66.  Formulation & Evaluation of Hibiscus rosa sinensis flower extract emulgel for Antibacterial Activity.doi: 10.48047/AFJBS.6.Si4.2024.6196-6208 [SCOPUS]. 

67.  Nanoemulgel: An Innovative Approach for Effective Topical Drug Delivery. https://doi.org/10.37896/HTL28.12/7518 (SCOPUS) 7.

68.  Garcinia indica (Kokum): An Overview of Its Phytochemical and Pharmacological Importance. https://doi.org/10.37896/HTL29.01/8002.

69.  Formulation and In Vitro Evaluation of Floating Tablets of Itopride Hydrochloride, Nat. Volatiles & Essent. Oils.https://doi.org/10.53555/nveo.v8i2.5809 [SCOPUS]

70.  HPTLC Analysis of Senna occidentalis (L.) in the Methanolic extract of the leaf DOI: 10.52711/0974-360X.2024.00037

71.  Pharmacological evaluation of combined neuroprotective effect of Melatonin and Simvastatin against LPS and STZ induced memory impairment in rodents DOI: https://doi.org/10.31024/ajpp.2019.5.2.15.

72.  Involvement of neuroinflammatory mediators in the pathogenesis of neurodegeneration DOI: https://doi.org/10.31024/ajpp.2020.6.1.2,9.

73.  Pharmacological evaluation of anti-diabetic effects of combined doses of momordica charantia and stevia rebaudiana against stz induced diabetes model (Doi: 10.13040/ijpsr.0975-8232.11(2).832-38,

74.  Pharmacological evaluation of anti-ulcer effects of combined doses of aloe vera and vitamin-e against indomethacin induced peptic ulcer model. Doi: 10.13040/ijpsr.0975-8232.10(10).    

75.  Investigative studies on pharmacological potential of HDAC inhibitor on heavy metal induced Neurodegeneration. DOI:10.31024/ajpp.2019.5.5.2

76.  Micelles Supported Organic Reactions in Water: A Review” Organic Chemistry: An Indian Journal 2022, 16, 1-16, ISSN: 0974-7516; DOI: 10.37532/0974-7516.22.16.001

77.  Synthetic and biological utility of 2,3-dichloro-1,4-naphthoquinone: a review International Journal of Research -GranthaalayahDOI: 10.5281/zenodo.3525162

78.  Carcinogenic Chemicals Causing Breast Cancer, Their Diagnosis and Treatment https://www.remedypublications.com/world-journal-of-breast-cancer-research-articles.php?vol=2&&iss=1

79.  Recent development of biodegradation techniques of Polymer” https://doi.org/10.5281/zenodo.1311065                  

80.  A “Photophysical and electrochemical studies of highly congested pyrazole and imidazole containing heterocycles” https://doi.org/10.1016/j.dyepig.2016.09.030. 

81.  Oxidizing Agent Applied for Quinone Synthesis: A Review” Organic Chemistry: An Indian Journal  https://www.tsijournals.com/abstract/oxidizing-agent-applied-for-quinone-synthesis-a-review-7423.html  

82.  Choline chlorideas an efficient catalyst for the synthesis of styryl-pyrazoles” Synthetic Comm. https://doi.org/10.1080/00397911.2016.1185124  9.                   

83.  “Synthesis of 4-phenyl-5,6-dihydrobenzo[h]quinazolines and their evaluation as growth inhibitors of carcinoma cells” RSC Advances 2016, 6, 18607-18618, ISSN 2046-2069; https://doi.org/10.1039/C5RA24429C  10.                      

84.  Synthesis, photophysical and anticancer study of D-ring extended estrone analogues”https://doi.org/10.1039/C5RA11112A  11.                     

85.  Crystal structures of four δ-keto esters and a Cambridge Structural Database analysis of cyano–halogen interactions”https://doi.org/10.1107/S2053229615017106  12.                   

86.  Strategy to Construct Stair Shaped Partially Reduced Naphtho[1,2-b]pyrano[2,3-d] oxepines  and Dinaphtho[1,2-b,d]oxepines”  https://doi.org/10.1002/jhet.2342 

87.  Natural and synthetic molecular medicine in cancer research: a review” ; https://www.opensciencepublications.com/fulltextarticles/JCRMM-1-101.html 14.                  

88.  Synthesis and biological evaluation of substituted 4,6-diarylpyrimidines and 3,5-diphenyl-4,5-dihydro-1H-pyrazoles as anti-tubercular agents.10.1016/j.bmcl.2014.04.094.

89.  Medicinal importance of Spanish cherry: An ornamental tree in human welfare from Dibrugarh District (Assam) India DOI: https://doi.org/10.47750/pnr.2022.13.S10.112%20%20,

90.  In silico Approaches for Exploring the Pharmacological Activities of Benzimidazole Derivatives: A Comprehensive Review DOI: 10.2174/0113895575287322240115115125,

91.  Pathophysiology of cerebral ischemia-reperfusion injury: An overview of oxidative stress and plant-based therapeutic approaches-https://doi.org/10.1016/j.brainres.2024.149308

92.  Standardization and Phytochemical screening of Carica papaya seedsDOI: 10.52711/0974-360X.2021

93.  Pharmacognostic Evaluation and Establishment of Quality Parameters of Leaves of Prosopis cineraria.DOI: 10.52711/0974-360X.2022.00102  

94.  HPTLC Phytochemical Profiling and Simultaneous Quantification of Quercetin and Gallic acid in Neolamarckia cadamba (Roxb.) DOI:10.52711/0974-360X.2024.00042      

95.  2. HPTLC Phytochemical Profiling and Simultaneous Quantification of Quercetin and Gallic acid in Prosopis juliflora (Sw.)  DOI:10.52711/0974-360X.2024.00590

96.  . Photodynamic Therapy of Cancer: Quality and Prospective of Therapy based on Photosensitizer. Current Cancer Therapy Reviews. doi.org/10.2174/1573394719666230119142053   

97.  Precision Medicine in Cancer Biology: Using Genetic and Molecular Profiling to Personalize Treatment. International Journal of Research and Innovation in Applied Science. https://doi.org/10.51584/IJRIAS.2024.90219

98.  Transforming Transcriptomics: The Impact of RNA Sequencing Technology”. https://doi.org/10.9734/ajmah/2024/v22i101103.

99.  Phytochemical analysis and simultaneous quantification of quercetin and gallic acid in Ipomoea carnea 10.31838/ecb/2023.12.5.423,

100.                   Simultaneous quantification of quercetin and gallic acid in methanolic extract of Heliotropium indicum, 10.48047/ecb/2023.12.10.696

101.                   Engineered Nanoparticle Therapy for Burn Wound Treatmenthttps://doi.org/10.2174/1389201022666210823110532)    

102.                   Exploring Liposomes for Lung Cancer Therapy (https://doi.org/10.1615/CritRevTherDrugCarrierSyst.2021037912)   

103.                   Recapitulate genistein for topical applications including nanotechnology delivery (https://doi.org/10.1080/24701556.2022.2048021)  

104.                   Exploring Nanoemulsions for Prostate Cancer Therapy (https://doi.org/10.1055/a-1518-6606)

105.                   Engineered nano scale formulation strategies to augment efficiency of nutraceuticals  (https://doi.org/10.1016/j.jff.2019.103554)    

106.                   Nanotechnology based strategies for nutraceuticals: A review of current research development   (https://doi.org/10.1615/NanoSciTechnolIntJ.2019030098)   

107.                   Nanoemulsion: An Advanced Vehicle For Efficient Drug Delivery (https://doi.org/10.1055/s-0043-115124)

108.                   Development and Assessment of  Dispersible Tablets Containing  Lomefloxacin HCl 10.31031/MAPP.2023.03.000562

109.                   Characterization of terpenoids isolated from Curcuma Amada Intellectual property India 2021.https://doi.org/10.47750/pnr.2022.13.S10.112%20%20

110. 115.Oral Disintegratin Tablets of Proton Pump Inhibitors for Chronic Gastroesophageal Reflux Disease: An Update.10.2174/2589977515666230221160449.
111. 116.Enteric coated microgranules of pantoprazole sodium in gastroesophageal reflux disease.http://dx.doi.org/10.54085/ap.2023.12.1.97
112. 117.Stability indicating HPLC method for in-vitro determination of Pantoprazole Sodium and its degradation products in simulated gastric and intestinal fluids.: 10.2174/0115734129254806231127110951
113. 118.Development and Efficacy Assessment of Polyherbal Phytosomal Gel for Accelerated Wound Healing.doi:10.1080/09205063.2024.2346400.